TABLE 2.
AUC, sensitivity, and specificity for ROC curves calculated at optimal cutoff for ceramide (d18:1/16:0), 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol, 12(R)-HETE, and cholesterol sulfate
| Significant metabolite by comparison group | AUCa | 95% CIb | Sensitivity (%) | Specificity (%) | P valuec | Fold change |
|---|---|---|---|---|---|---|
| TB vs controls | ||||||
| Ceramide (d18:1/16:0) | 0.912 | 0.850–0.974 | 84.8 | 86.7 | 3.90E-08 | 26.15 |
| 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol | 0.856 | 0.758–0.853 | 89.1 | 80.0 | 5.55E-07 | 1.83 |
| 12(R)-HETE | 0.914 | 0.846–0.981 | 84.8 | 90.0 | 5.63E-03 | 4.19 |
| Cholesterol sulfate | 0.905 | 0.829–0.981 | 87.0 | 86.7 | 4.73E-10 | 6.09 |
| TB vs CAP | ||||||
| Ceramide (d18:1/16:0) | 0.717 | 0.595–0.840 | 71.7 | 66.7 | 5.24E-03 | 3.82 |
| 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol | 0.894 | 0.816–0.972 | 84.8 | 83.3 | 9.78E-10 | 2.16 |
| 12(R)-HETE | 0.793 | 0.683–0.904 | 89.1 | 63.3 | 2.32E-02 | 4.69 |
| Cholesterol sulfate | 0.802 | 0.693–0.911 | 80.4 | 70.0 | 6.46E-05 | 3.75 |
a
AUC, area under the receiving operating characteristic curve.
b
CI, confidence interval.
c
All P values were calculated using Student's t test.