TABLE 3.
Sensitivities and specificities of combinations of two or three metabolites for differentiation between TB and controls or CAP
| Metabolites | TB vs controls |
TB vs CAP |
||
|---|---|---|---|---|
| Sensitivity (%) | Specificity (%) | Sensitivity (%) | Specificity (%) | |
| Ceramide (d18:1/16:0) + 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol | 76.1 | 90.0 | 65.2 | 90.0 |
| Ceramide (d18:1/16:0) + 12(R)-HETE | 69.6 | 100.0 | 60.9 | 76.7 |
| Ceramide (d18:1/16:0) + cholesterol sulfate | 84.8 | 86.7 | 67.4 | 73.3 |
| 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol + 12(R)-HETE | 73.9a | 100.0 | 73.9 | 96.7 |
| 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol + cholesterol sulfate | 78.3 | 90.0 | 71.7 | 96.7 |
| 12(R)-HETE + cholesterol sulfate | 71.7 | 100.0 | 67.4 | 80.0 |
| Ceramide (d18:1/16:0) + 12(R)-HETE + cholesterol sulfate | 69.6 | 100.0 | 56.5 | 80.0 |
| 4α-Formyl-4β-methyl-5α-cholesta-8-en-3β-ol + 12(R)-HETE + cholesterol sulfate | 63.0 | 100.0 | 60.9 | 100.0 |
| Ceramide (d18:1/16:0) + 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol + 12(R)-HETE | 60.1 | 100.0 | 54.4 | 96.7 |
| Ceramide (d18:1/16:0) + 4α-formyl-4β-methyl-5α-cholesta-8-en-3β-ol + cholesterol sulfate | 76.1 | 90.0 | 63.0 | 96.7 |
a
Combinations with sensitivity of ≥70% and specificity of ≥90% for both comparisons (TB versus controls and TB versus CAP) are in bold.