Fig. 2.
Twenty-four-hour total food consumption was reduced in a dose-dependent manner following IP injection of either PACAP1–38 or PACAP1–27 before the dark phase in WT but not in PAC1−/− mice. A: PACAP1–38 injected in WT mice compared with vehicle. B: PACAP1–27 injected in WT mice compared with vehicle. C: PACAP1–38 injected in PAC1−/− mice compared with vehicle. Data are means ± SE of 16 mice/group. ****P < 0.0001, 10 μM vs. vehicle. ###P < 0.001; ####P < 0.0001, 1 μM vs. vehicle. ×P < 0.05; ××P < 0.01, 100 nM vs. vehicle.