Skip to main content
. 2015 Nov 19;5:16830. doi: 10.1038/srep16830

Table 3. Main functions and pathways enriched in each moduleofthe GeneMania network.

Module Number of proteins Main enriched functions and pathways
1 97 MAPK signaling pathway, toll-like receptor cascade, autophagy, cellular senescence
2 84 apoptosis, DNA damage response, cytoplasmic ribosomal proteins, ATM signaling pathway, regulation of cell cycle progression, p53 pathway
3 94 amino acid metabolism, unfolded protein response, antigen processing and presentation, ubiquitin-proteasome system
4 17 Mitotic G1-G2/M phases, centrosome maturation
5 8 detoxification of reactive oxygen species, cellular response to stress
6 112 focal adhesion, regulation of actin cytoskeleton, ECM-receptor interaction, cytokine-cytokine receptor interaction, NGF, PDGF, SCF-Kit, DAP12 and PI3K/Akt pathways.
7 16 apoptosis
8 19 matrix metalloproteinases, Insulin-like growth factor uptake
9 15 TGF-β receptor signaling pathway
10 9 cell cycle and mRNA processing