Table 4. Main functions and pathways enriched in each module of the HS network.

Module	Number of proteins	Main enriched functions and pathways
1	86	Cytokine-cytokine receptor interaction, melanoma, JAK-STAT signaling pathway, MAPK signaling pathway, TLR signaling pathway, apoptosis, glioma, ESC Pluripotency Pathways, IL-1 pathway, senescence and autophagy, signaling by ERBB4, SCF-KIT, ERBB2, FGFR andPDGF
2	12	mRNA processing, Mitotic anaphase, negative regulation of the PI3K/AKT network
3	13	Tight junction, calcium signaling pathway, signaling pathways in glioblastoma, endothelin pathway, DNA damage response, calcitonin-like ligand receptors, negative regulation of the PI3K/AKT network
4	33	Regulation of action cytoskeleton, adherens junctions, cell cycle, ATM signaling pathway, TP53 signaling pathway, DNA damage response, EPH-Ephrin signaling
5	55	ECM receptor interaction, focal adhesion, cell communication, WNT signaling pathway, IL6 and IL3 pathways, TGF-beta signaling pathway, negative regulation of MAPK cascade
6	15	Ribosome, NOD pathway, translation factors, caspase cascade in apoptosis
7	54	MAPK signaling pathway, apoptosis, cellular response to stress, toll-like receptor cascade,
8	17	Notch signaling pathway, calcium signaling pathway, insulin signaling pathway