FIG. 4.
Gross appearance and subchondral bone remodeling of cartilage defects after 12 weeks in vivo. (A) Representative gross images (i.e., median overall gross scores, which are shown in inset) and (B) overall gross score for all cartilage defects (n = 7–10). Note that normal tissue overall gross score = 0. (C) Subchondral bone remodeling, as quantified through area without bone underneath the cartilage (mm3) (n = 7–10). (D) Representative microCT reconstructions depicting cartilage (orange) and bone (green), with the area without bone underneath the cartilage outlined. *p < 0.05 between specified groups and **p < 0.05 in comparison to all other groups. microCT, microcomputed tomography. Color images available online at www.liebertpub.com/tea