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. 2015 Nov 19;5:16811. doi: 10.1038/srep16811

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(a–d): Altered composition of functional AP-1 complex in HPV^+ve and HPV^−ve tongue tumor tissues and cell lines. Band supershift assay using specific antibodies (Abs) against all AP-1 family members (c-Jun, JunB, JunD, c-Fos, FosB, Fra-1, Fra-2). Panel a, b, c and d showing differential binding activity of AP-1 members in HPV^+ve (a) and HPV^−ve (b) TSCCs and tumor cell lines; UPCI:SCC090;HPV16^+ve(c) and AW13516; HPV^−ve(d). In all panels (a–d) significantly a higher (~90) binding of c-Fos and Fra-2 forms the functional AP-1 complex. HPV^+ve TSCC (panel a) shows a minor participation of JunD and JunB while c-Jun selectively participates in HPV^−ve tumors (panel b). The arrowhead indicates the supershifted bands. The intensities of super-shifted bands indicated and quantified in densitometric analysis. NS; non-specific binding.