Table 1.
14 days | 28 days | 56 days | |||||||
---|---|---|---|---|---|---|---|---|---|
Acellular | Suture | Acellular | Cellular | BMP2 | Suture | Acellular | Cellular | BMP2 | |
Cellularity | 3.5 (2, 4) | 1 (1, 1) | 3 (2, 3) | 2 (2, 3) | 2 (1, 3) | 2 (1, 3) | 3 (3, 3) | 2 (2, 2) | 2.5 (2, 3) |
Fibroblasts | 2.5 (1, 4) | 1 (1, 1) | 2 (1, 3) | 3 (2, 3) | 1.5 (1, 3) | 2 (1, 3) | 2 (2, 2) | 1.5 (1, 2) | 2 (1, 3) |
Vascularity | 3 (2, 4) | 3 (3, 3) | 2 (2, 3) | 2 (2, 3) | 3 (2, 4) | 2 (2, 2) | 2.5 (2, 3) | 2.5 (2, 3) | 3.5 (3, 4) |
Matrix | 3 (2, 4) | 1.5 (1, 3) | 2 (2, 3) | 3 (2, 3) | 2 (2, 3) | 2 (1, 3) | 2 (2, 2) | 2 (2, 2) | 1.5 (1, 2) |
Cell orient | 3 (1, 4) | 1.5 (1, 2) | 2 (2, 2) | 2 (2, 3) | 2 (2, 3) | 1.5 (1, 2) | 2 (2, 2) | 2 (2, 2) | 1.5 (1, 2) |
Coll. orient | 4 (2, 4) | 2 (2, 2) | 3 (3, 3) | 3 (2, 3) | 2.5 (1, 3) | 2.5 (2, 3) | 2 (2, 2) | 2.5 (2, 3) | 2 (2, 2) |
Ins. histo. | 3.5 (2, 4) | 2 (1, 3) | 3 (3, 3) | 3 (1, 3) | 2.5 (1, 3) | 3 (2, 4) | 2 (2, 2) | 3 (3, 3) | 2 (2, 2) |
Ins. cont. | 4 (2, 4) | 2 (2, 3) | 3 (3, 3) | 3 (2, 3) | 2.5 (1, 3) | 2.5 (2, 3) | 2 (2, 2) | 2.5 (2, 3) | 2 (2, 2) |
Maturity | 26.5 (14, 32) | 14.5 (12, 17) | 20 (19, 22) | 22 (15, 23) | 18 (12, 24) | 17.5 (12, 23) | 17.5 (17, 18) | 18 (17, 19) | 17 (14, 20) |
Each outcome was scored from 1 (closest to normal) to 4 (most abnormal). The sum of scores was used as an indication of enthesis maturity (8: normal, 32: furthest from normal). Specifically, cellularity (4: high, 1: low), fibroblasts (4: <25% of total, 3: 26–50%, 2: 51–75%, 1: >75%), vascularity (4: 15 bv/low PF, 3: 11–15 bv/low PF, 2: 6–10 bv/low PF, 1: <6 bv/low PF), matrix (4: minimal, 1: marked), cells parallel (4: <25%, 3: 26–50%, 2: 51–75%, 1: >75%), collagen orientation (4: <25% fibers parallel, 3: 26–50%, 2: 51–75%, 1: >75%), insertion histological findings (4: lacks fibrocartilage/regularity/tidemark, 3: regularity but lacks fibrocartilage/tidemark, 2: regularity and fibrocartilage but lacks tidemark, 1: regularity/fibrocartilage/tidemark present), insertion continuity (4: <25%, 3: 26–50%, 2: 51–75%, 1: >75%). Data are presented as median (range).
BMP2, bone morphogenetic protein 2; bv, blood vessels; PF, power field.