Table 5.
GRADE assessments for the body of evidence for each outcome and judgment of the overall quality of evidence
| Outcome | Follow-up | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Overall quality of evidence |
|---|---|---|---|---|---|---|---|
| Primary outcomes | |||||||
| Change in CT score | |||||||
| Lund-McKay Score | 16 weeks | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Percent opacification on CT | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Change in clinical polyp score | |||||||
| Total nasal endoscopic polyp score | 16 weeks; 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Change in quality of life | |||||||
| SF-36 | 16 weeks | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| AQLQ | 16 weeks | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| RSOM-31 | 16 weeks | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| TNSS | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| SNOT-20 | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Secondary outcomes | |||||||
| Change in cellular inflammation | |||||||
| Eosinophil count (nasal lavage) | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Change in nasal airflow | |||||||
| PNIF | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Change in olfaction | |||||||
| UPSIT | 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
| Adverse events | 16 weeks; 6 months | Moderate limitation | Not relevant | No serious indirectness | Serious imprecision | Unlikely | Low |
SF-36 36-Item Short Form Health Survey, AQLQ Asthma Quality of Life Questionnaire, RSOM-31 Rhinosinusitis Outcome Measure 31, TNSS Total Nasal Symptom Severity, SNOT-20 Sinonasal Outcome Test 20, PNIF peak nasal inspiratory flow, UPSIT University of Pennsylvania Smell Identification Test