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. 2015 Nov 18;5:64. doi: 10.1186/s13578-015-0053-7

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© Wu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effects of ouabain on TAC-induced cardiac dysfunction in Con and p85-KO mice. Experiments were done as described in “Methods”. Left ventricular cardiac functions were monitored by echocardiography before and after 8 weeks of the TAC or sham surgery. Ouabain was infused subcutaneously (50 μg/kg/day) by ALZET osmotic pumps for continuous dosing for the first 4 weeks. a Fraction shortening, FS % in Con and KO mice. b representative echocardiographic M-mode views of mouse left ventricles at week 8 after surgery. c myocardial performance index (MPI) in Con and KO mice. d representative Pulsed-Wave Doppler flow used for MPI calculation. n = 6 ~ 7, *P < 0.05 vs. Sham;^# P < 0.05 vs. TAC