Table 1.
Echocardiographic analysis (baseline) of Con and p85-KO mouse hearts
| BW (g) | HR (bpm) | EDA (cm2) | ESA (cm2) | PWT (cm) | SWT (cm) | RWT | MPI | FS | LV mass (g) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Con | 31.8 ± 1.2 | 439 ± 9 | 0.168 ± 0.004 | 0.088 ± 0.003 | 0.114 ± 0.003 | 0.104 ± 0.003 | 0.60 ± 0.02 | 0.36 ± 0.03 | 0.45 ± 0.02 | 0.126 ± 0.004 |
| KO | 28.4 ± 1.0 | 438 ± 11 | 0.153 ± 0.004* | 0.081 ± 0.004 | 0.108 ± 0.005 | 0.087 ± 0.002* | 0.54 ± 0.02 | 0.30 ± 0.02 | 0.45 ± 0.01 | 0.105 ± 0.005* |
The p85-KO and the Cre controls (12–16 week-old, male) were subjected to echocardiography analysis
BW body weight; HR heart rate; EDA end diastolic area; ESA end systolic area; PWT posterior wall thickness; SWT septal wall thickness; RWT relative wall thickness; MPI myocardial performance index; FS fractioning shortening; LV mass left ventricular mass; Con n = 21; KO n = 15
* p < 0.05 v.s. Con