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Inhibition of UB transfer through the E1-E2-E3 cascade by the UB-mimicking peptides. (A) Inhibition of the formation of UB~Ube1 conjugate by peptides P2, P3 and P4. (B) Inhibition of CHIP polyubiquitination by increasing concentrations of the P3 and P4 peptides. (C) Inhibition of UB transfer to the HECT domain of E6AP by increasing concentrations of P3 and P4 peptides. 5 µM HA-UB was added in each reaction after preincubation with the peptides.
