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. Author manuscript; available in PMC: 2015 Nov 19.
Published in final edited form as: ACS Chem Biol. 2015 Jan 5;10(3):855–863. doi: 10.1021/cb500872g

Figure 4.

Figure 4

Cys275 of NPM1 Mutant A is required for the nucleolar relocalization of NPM1 by avrainvillamide. (A) HCT-116 cells transfected with eGFP-NPM plasmids and treated with DMSO (vehicle control) or avrainvillamide (1 μM, 24 h). Colors: green, eGFP; red, nucleolin; blue, DNA. Scale bar = 10 μm. (B) Subcellular localization of the eGFP-NPM Mutant A-derived constructs following treatment with DMSO or avrainvillamide. For each dosing condition, a minimum of 150 cells was counted in each of three separate experiments. Error bars indicate mean ± standard deviation.