Table 3.

Performance of screening tool models for detecting patients with DDIs using combinations of risk factors

Risk score: Screen patients with two or more of the following risk factors	ROC AUC (95% CI)	Sensitivity	Specificity	Patients screened (%)	Patients with DDIs detected (%)	Number of DDIs detected (% of DDIs in cohort)	Contraindicated combinations detected (test sample, 2/500; main sample, 4/2000)
Model 1	0.80 (0.76–0.83)	89.7%	56.1%	264 (52.8)	87 (89.7)	133 (91.1)	T: 2
WHO stage 3–4							M: 4
anti-infective
PI regimen
at least two comedications
Model 2	0.82 (0.79–0.86)	74.2%	82.9%	141 (28.5)	72 (74.2)	109 (74.7)	T: 2
anti-infective							M: 4
PI regimen
at least two comedications
Model 3	0.69 (0.64–0.73)	75.2%	58.5%	240 (48.0)	73 (75.3)	114 (78.0)	T: 2
WHO stage 3–4							M: 3
PI regimen
at least two comedications

T, test sample; M, main sample.