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Synthesis of phosphoramidite building block. i) 2,2-dibenzylpropane-1,3-diol 1 (1.0 g, 3.9 mmol), 4,4′-dimethoxytrityl chloride (0.69 g, 3.9 mmol), 4-dimethylaminopyridine (2.5 × 10−2 g, 0.21 mmol) dry Py (10.0 mL), dry CH3CN (10.0 mL), 2.5 h, yields 40%; ii) 2 (0.425 g, 0.76 mmol), β-cyanoethyl-N,N’-diisopropyl-chloro-phosphoramidite (0.270 mL, 1.2 mmol), DIPEA (0.530 mL, 3.0 mmol), dry DCM (8 mL), 1.0 h, 85%.
