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. 2015 Aug 10;43(16):7779–7789. doi: 10.1093/nar/gkv810

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — The main connected components of protein-protein interaction network of the cancer-specific differential genes. Up-regulated genes in cases versus negatives and BGCs are in red, down-regulated genes are in green. The large connected component (left) can be separated into two up-regulated sub-modules by removing the down-regulated genes. The down regulated genes are related to cytoskeleton, whereas the sub-modules contain mitosis, replication, and cell cycle genes. The small connected component (right) also contains mainly up-regulated genes, and has TP53 as the main hub.