Table 1.

Summary of CB₁R and FAAH influence on non-cannabinoid drug reward.

	EtOH	Nicotine	Opiates	Stimulants
CB1 R KO	CPP Self-Admin. EtOH-induced NAc DA	CPP Self-Admin.	CPP Self-Admin.	n/c CPP n/c Self-Admin.
CB1R Antagonist	Self-Admin. Preference EtOH-induced NAc DA	CPP Self-Admin. NIC-induced NAc DA	CPP Self-Admin. n/c MORPH-induced NAc DA	Self-Admin (AM251) COC effects on ICSS n/c COC-induced NAc DA
CB1R Agonist	Self-Admin. Motivation for EtOH	CPP	CPP Motivation for heroin	Self-Admin COC effects on ICSS
FAAH Inhibition	Self-Admin. Preference	CPP (mouse, CB1R) CPP (rat, non-CB1R) Self-Admin (rat, non-CB1R) NIC-induced NAc DA (rat, non-CB1R)	n/c Self-Admin n/c MORPH-induced VTA DA excitation	n/c COC-induced VTA DA excitation n/c Self-Admin

EtOH, ethanol; NIC, nicotine; MORPH, morphine; COC, cocaine; CPP, conditioned place preference; n/c. no change; Self-Admin., operant self-administration; Preference, relative consumption of EtOH vs. water; ICSS, intracranial self-stimulation (an index of brain reward function);