Figure 4. Percentage of patients with type of variants seen by tumor type.

The data was reviewed according to tumor type a)nd demonstrated great variation in the proportion of KRAS, potentially actionable somatic mutations excluding KRAS, non-actionable somatic, likely germline variants, and absence of mutations found using our 46 gene panel. While sarcoma has the fewest number of mutations/variants detected, pancreatic tumors had no germline variants found and melanoma had the largest proportion of potentially actionable mutations detected. Many of these findings may represent the inherent selection bias of mutations represented on the gene panel, which has been focused on identifying known actionable mutations with potential therapeutic targets.