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. 2015 May 8;6(24):20177–20189. doi: 10.18632/oncotarget.3896

Figure 4. GSK3β enhances chemo-sensitivity in tongue cancer cells.

Figure 4

A–E. GSK3β protein levels were detected by western blotting in cells transfected with GSK3β expressing plasmid or siRNA. GSK3β overexpression enhanced the sensitivity of TC cells to PYM and cDDP with reduction of IC50 values, but GSK3β knockdown attenuated the chemo-sensitivity of TC cells with increase of IC50 values detected by MTS proliferation assays. F. 24 h after cells transfected with pLV-GSK3β or siRNA, the TCF/LEF Reporter Assays were performed to determine the effects of GSK3β on β-catenin activation. *p < 0.05, **p < 0.01.