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. 2015 May 8;6(24):20215–20230. doi: 10.18632/oncotarget.4046

Figure 3. Effects of FGFR siRNA silencing.

Figure 3

A. FGFR1, FGFR2, FGFR3 and FGFR4 protein expression in MLS cell lines detected by western blot analysis. B. Apoptosis induction upon FGFR siRNA silencing in MLS cell lines, either of the different receptors alone (top) or combined knock-down of several FGFRs (bottom). As negative control cells were transfected with Stealth RNAi™ Negative Control Duplexes with the corresponding GC content (Contr. F1, F2, F3, F4). AllStars Hs Cell Death siRNA served as transfection control and as positive control for apoptosis induction (Pos.Contr.). Data of quintuplicates are represented as mean +/− SEM. *: p ≤ 0.05; **: p ≤ 0.01; ***: p ≤ 0.001. F1:FGFR1; F2:FGFR2; F3: FGFR3; F4:FGFR4. C. Effects of FGFR silencing on downstream signaling in MLS cell lines 48 h after transfection with specific siRNAs. As negative control cells were transfected with Stealth RNAi™ Negative Control Duplexes with the corresponding GC content.