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. 2015 May 4;6(24):20419–20433. doi: 10.18632/oncotarget.3983

Figure 4. PRR11 knockdown inhibits cell proliferation and cell migration in vitro and in vivo.

Figure 4

A. The mRNA level of PRR11 in PRR11-siRNA (KO) and empty vector (WT) transfected cells. B. Levels of PRR11 protein in WT and PRR11-KO groups. C. CCK8 assay demonstrates the ratio of cellular proliferation in two groups. D. Colony formation assays in WT and PRR11-KO groups. E. Transwell assay demonstrating the effects of PRR11-knockdown on cell migration. F. Flow cytometric analysis demonstrating the cell cycle distributions of the two cell lines. **P < 0.01, ***P < 0.001 compared to the control. G. H. PET scan showed tumor location, distribution, and tumor size in the control group (G, g) and in the PRR11-KO group (H, h). (I, i) IHC showed strong expression of PRR11 in resected tumors from the WT group I. and negative staining of PRR11 in resected tumors from the PRR11-KO group (i). IHC×400.