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Wnt signaling is activated in cutaneous wounds after injury. A) Heat map generated from gene expression array of Wnt pathway-associated genes. B) qRT-PCR validation of change in expression of Wnt agonists (Wnt3a), and Wnt direct transcriptional targets (Dkk1, CyclinD1, and c-Myc), and Wnt inhibitor (sFRP2). MRL-uninjured: n = 1; all other groups: n ≥ 3 per group.
