Figure 3.

Wnt inhibitor treatment promotes closure of ear punch wounds. Images of 2 mm ear punch holes treated topically for 30 d with (A) small-molecule Wnt inhibitor XAV-939 (right panel) or contralateral control treated with vehicle only (DMSO; left panel); (B) small-molecule Wnt inhibitor Pyr (right panel) or a nonfunctional analog, compound 211 (left panel); (C) small-molecule Wnt inhibitor, analog of Pyr (C-113; right panel) or 211 (left panel); and (D) Wnt activator LiCl (right panel) or vehicle (PBS; left panel). The histograms underneath the panels represent quantification of percent closure of ear punches at d 30. Bars represent means ± sd. *P ≤ 0.05 and **P ≤ 0.01 were calculated using paired Student's t test with (A) n = 10, (B) n = 6 per group, (C, D) n = 5 per group.