TABLE 1.

Prevalence of autoantibodies recognizing 40-60 kDa liver antigens

Genotype	Age (mo)	Total (n)	AMA positive		Phenotype
			%	n	Liver	Colon
K8+/+ M + F	2–18	51	6	3	N	N
K8+/− M + F	8–18	16	6	1	N	N/Ab
K8−/− M + Fa	2–7	16	0	0	A	A
M + F	8–24	60	57	34	A	A
M	8–24	27	81	22	A	A
F	8–24	6	0	0	A	A
K18−/− M	11–12	20	75	15	A	N

A, abnormal histology; N, normal histology. ^aSeventy-five percent males. ^bK8^+/− colon appears normal but has a mild phenotype (19).