This figure presents the results for the high pain regressor and the ratings regressor from the hierarchical regression where regressors were entered in the following order from first to last: low pain, high pain, button press, ratings. Of note the ratings regressor captured more extensive and unique positive activation above and beyond that of the high pain regressor. Panel A (top) shows areas of unique variance associated with the high pain regressor (HP; red), the ratings regressor after correcting for variance associated with the button press regressor (RatingsBP) (yellow), and overlap between the two (orange). Panel B (bottom) shows areas of unique variance associated with HP (dark blue), RatingsBP (light blue) and Overlap (medium blue). Regions indicated by arrows include 1) insula (Ins); 2) thalamus (Thal); 3) anterior cingulate cortex (ACC); 4) dorsolateral prefrontal cortex (DLPFC); 5) inferior parietal lobule (IPL); 6) rostral/subgenual ACC (r/sgACC). Slice locations (Z) are given according to the Talairach atlas.