Table 2.
SNP | Gene | No. of subjects | P value | P corr | Minor allel | MAF % |
---|---|---|---|---|---|---|
Males | ||||||
rs8031741 | ACAN | 159 | 9.57E−26 | <0.001 | G | 0.3 |
rs2271649 | ADAM12 | 158 | 5.12E−07 | <0.001 | A | 0.9 |
rs16859850 | CCDC80 | 158 | 4.08E−17 | <0.001 | G | 0.6 |
rs2300792 | COL12A1 | 157 | 1.43E−22 | <0.001 | C | 0.3 |
rs16918099 | COL15A1 | 159 | 3.29E−05 | 0.005 | A | 0.2 |
rs16918124 | COL15A1 | 159 | 6.19E−05 | 0.008 | C | 0.5 |
rs7863250 | COL15A1 | 159 | 6.19E−05 | 0.008 | C | 0.5 |
rs2672826 | COL23A1 | 157 | 4.74E−04 | 0.048 | A | 12.1 |
rs12477499 | COL3A1 | 159 | 2.49E−14 | <0.001 | G | 0.3 |
rs12589592 | FBLN5 | 159 | 2.13E−04 | 0.023 | A | 33.1 |
rs12050562 | FBN1 | 159 | 8.75E−05 | 0.010 | T | 0.8 |
rs7606877 | GPC1 | 159 | 1.41E−14 | <0.001 | A | 0.5 |
rs9492168 | LAMA2 | 158 | 7.50E−17 | <0.001 | T | 0.3 |
rs2158836 | LAMB1 | 159 | 1.75E−04 | 0.020 | A | 37.1 |
rs10911215 | LAMC1 | 159 | 1.11E−09 | <0.001 | T | 1.3 |
rs2513812 | MATN2 | 159 | 4.36E−09 | <0.001 | G | 1.3 |
rs1151578 | NID2 | 158 | 2.53E−08 | <0.001 | T | 0.2 |
rs6480654 | P4HA1 | 157 | 2.67E−12 | <0.001 | A | 0.2 |
rs1382192 | PDIA4 | 159 | 4.90E−13 | <0.001 | A | 0.5 |
rs4727007 | PDIA4 | 159 | 4.90E−13 | <0.001 | G | 0.5 |
rs10197695 | PDIA6 | 159 | 1.26E−14 | <0.001 | G | 0.3 |
rs7323378 | POSTN | 158 | 1.10E−05 | 0.002 | C | 48.0 |
rs9547947 | POSTN | 149 | 2.62E−05 | 0.004 | A | 38.3 |
rs9315503 | POSTN | 159 | 2.20E−04 | 0.023 | G | 33.9 |
rs7679471 | TLL1 | 159 | 3.36E−07 | <0.001 | C | 0.2 |
Females | ||||||
rs8031741 | ACAN | 309 | 5.14E−16 | 0.000 | G | 0.3 |
rs4871046 | COL14A1 | 307 | 5.49E−09 | 0.000 | C | 0.5 |
rs16918099 | COL15A1 | 310 | 5.75E−44 | 0.000 | A | 0.2 |
rs12477499 | COL3A1 | 310 | 2.19E−43 | 0.000 | G | 0.3 |
rs17516906 | FN1 | 303 | 1.28E−04 | 0.040 | G | 7.4 |
rs1151578 | NID2 | 310 | 5.19E−06 | 0.002 | T | 0.2 |
rs11925421 | PLOD2 | 310 | 7.20E−10 | 0.000 | G | 0.6 |
rs7078493 | TLL2 | 310 | 5.19E−06 | 0.000 | T | 0.2 |
rs310517 | VCAN | 310 | 1.79E−25 | 0.000 | T | 0.5 |
P values are derived from univariate linear regression analyses, and P corr are P values corrected for false discovery rate. P corr values <0.05 are considered significant, and SNPs with a MAF < 5 % are excluded. SNPs in bold have P corr values <0.05 and MAF > 5 %
MAF minor allel frequency