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. 2015 Oct 28;112(45):E6195–E6204. doi: 10.1073/pnas.1507052112

Fig. 1.

Fig. 1.

Prevention of severe autoimmune pathology with CD11c-Cre-normalization of TLR7. (A) TLR7 mRNA expression in pDCs and CD11b+ cDCs assessed by Nanostring in 6- to 8-wk-old mice (n = 4–5 or n = 3 per strain, respectively, for cDC and pDC). Five- to 7.5-mo-old Sle1, Sle1Tg7, and CD11cSle1Tg7 mice were analyzed for: (B) splenic size (n = 12–13 per strain); (C) concentrations of BUN (n = 13–19 per strain), GN, and interstitial renal disease (IN) scored from 0 to 4 and quantification of glomerular crescent formation (n = 6–9 mice per strain). (D) Analysis of chemokine levels in renal supernatants (n = 12–13 per strain) and (E) IFN-α levels in kidney supernatants by ELISA (n = 11–13 per strain). Bars represent mean + SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns, not significant (one-way ANOVA or Kruskal–Wallis test).