The Weiss Functional Impairment Rating Scale–Parent Report (WFIRS-P) provides specific information regarding domains of functional impairment in children with attention-deficit/hyperactivity disorder (ADHD).

Guanfacine extended release (GXR) treatment was associated with improvements in parent ratings of their child’s ADHD-related functional impairment, as measured by WFIRS-P, after 8 weeks of treatment.

Improvements on the WFIRS-P were observed for both morning and evening GXR administration.

Parent ratings of functional improvement on WFIRS-P were generally congruent with symptomatic and overall response to GXR treatment, as measured by ADHD Rating Scale IV (ADHD-RS-IV) and Clinical Global Impressions–Improvement Scale (CGI-I) scores, respectively.

The Life Skills and Self-Concept domains of the WFIRS-P did not improve with GXR treatment, which may signal a need for longer trials, or additional or more tailored psychosocial interventions.