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. 2015 Nov 20;5:256. doi: 10.3389/fonc.2015.00256

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Copyright © 2015 Jakobi, Lühr, Stützer, Bandurska-Luque, Löck, Krause, Baumann, Perrin and Richter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic drawing of the sub-volume TCP model approach. Empirical dose–response data from comparable patient cohorts – given as (A) dose–response curve and (B) spatial distribution of local failures (represented by the asterisks) – serve as input to generate (C) one dose–response curve for each target sub-volume. The total TCP results from the product of all sub-volume TCP. Note, all target sub-volumes have to be disjoint. Therefore, inner sub-volumes are excluded from outer encompassing structures.