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. 2015 Nov 20;6:587. doi: 10.3389/fimmu.2015.00587

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Copyright © 2015 Starzl, Wolfram, Zamora, Jefferson, Barclay, Ho, Gorantla, Brandacher, Schneeberger, Andrew Lee, Carbonell and Vodovotz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Factor analysis suggests distinct groups of inflammatory mediators induced in the “wound group” vs. the “cardiac arrest group” in skin and muscle. (A) Factor analysis (two factors) variable composition in skin. Modeled cytokine contribution to “cell-mediated cytotoxic response” and “macrophage activation” as calculated by linear combinations of provided latent factors. The direction of each vector indicates which factor the cytokine influences, while the length indicates the relative strength of influence as calculated by the model. (B) Factor analysis (two factors) variable composition in muscle. Modeled cytokine contribution to “macrophage activation” and “cell-mediated cytotoxic response” as calculated by linear combinations of provided latent factors.