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. 2015 Nov 20;3:75. doi: 10.3389/fcell.2015.00075

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Copyright © 2015 Yoneshige, Hagiyama, Fujita and Ito.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CADM1-mediated nerve–mast cell interaction in the atopic dermatitis skin lesion. Dermal mast cells are observed in contact with nerve fibers in the atopic dermatitis. These lesional mast cells express CADM1 at higher levels than those in the normal skin, which is induced by the basic helix-loop-helix type microphthalmia-transcription factor (MITF). CADM1-expressing mast cells interact with neurons to secrete substance P (SP), and the neuron-derived substance P further interacts with the cognate receptor neurokinin 1 (NK-1) expressed on the mast cells to induce their degranulation.