Table 1. Echocardiogram after 5-cell sheet construct TX to rat myocardial infarction model.
| Group | baseline | pre Tx | 1w | 2w | 4w | 8w | 12w | |
|---|---|---|---|---|---|---|---|---|
| LVDd (mm) | Sham | 6.4 ± 0.1 | 7.3 ± 0.2 | 7.3 ± 0.3 | 7.8 ± 0.4 | 8.2 ± 0.5 | 8.1 ± 0.3 | 9.2 ± 0.4 |
| 5-Control | 6.3 ± 0.2 | 7.5 ± 0.2 | 8.2 ± 0.1 | 8.0 ± 0.1 | 8.2 ± 0.1 | 8.9 ± 0.2 | 9.3 ± 0.3 | |
| 5-GHM | 6.2 ± 0.1 | 7.3 ± 0.2 | 7.6 ± 0.2 | 7.9 ± 0.2 | 8.1 ± 0.2 | 7.4 ± 0.7 | 8.2 ± 0.4 | |
| LVDs (mm) | Sham | 3.0 ± 0.1 | 5.6 ± 0.2 | 5.8 ± 0.3 | 6.2 ± 0.3 | 6.6 ± 0.5 | 6.6 ± 0.3 | 7.5 ± 0.4 |
| 5-Control | 3.0 ± 0.2 | 5.8 ± 0.2 | 6.1 ± 0.2 | 5.6 ± 0.3 | 6.2 ± 0.2 | 6.3 ± 0.2 | 6.4 ± 0.2 | |
| 5-GHM | 2.7 ± 0.1 | 5.5 ± 0.2 | 5.0 ± ± 0.2*†† | 5.1 ± 0.3 | 5.1 ± 0.3*† | 4.1 ± 0.6** | 4.5 ± 0.2** | |
| FS (%) | Sham | 53.9 ± 1.3 | 23.1 ± 1.4 | 20.7 ± 1.0 | 20.4 ± 1.2 | 19.1 ± 1.6 | 18.8 ± 1.3 | 18.7 ± 1.2 |
| 5-Control | 52.3 ± 1.7 | 23.1 ± 1.6 | 26.1 ± 1.3* | 29.8 ± 2.9* | 25.3 ± 1.7 | 29.5 ± 2.2* | 32.1 ± 0.9* | |
| 5-GHM | 56.6 ± 1.5 | 24.9 ± 0.7 | 34.9 ± 1.5**†† | 36.3 ± 2.1*** | 37.3 ± 2.7***†† | 45.4 ± 3.9** | 44.8 ± 1.7** | |
| Akinetic length (%) | Sham | 0.0 | 24.5 ± 3.3 | 29.3 ± 2.8 | 26.0 ± 2.0 | 28.2 ± 3.6 | 34.2 ± 5.2 | 29.2 ± 3.0 |
| 5-Control | 0.0 | 23.1 ± 3.1 | 14.9 ± 2.8* | 13.3 ± 3.0* | 16.6 ± 3.2 | 17.7 ± 1.6 | 19.1 ± 0.7 | |
| 5-GHM | 0.0 | 22.6 ± 1.7 | 5.5 ± 1.7***† | 5.4 ± 1.5*** | 0.5 ± 0.4***†† | 0.0***† | 0.0**† |
*p < 0.05, **p < 0.01 vs Sham, †p < 0.05, ††p < 0.01 vs 5-Control. Kruskal-Wallis test, post-hoc Steel-Dwass multiple comparison test, sham, n = 6; 5-control, n = 11; 5-GHM, n = 10.