Figure 4. pp38 reduction was observed after 3 or 7 days of ASC-CM treatment in SOD1^G93A mice spinal cords after disease onset.

SOD1^G93A mice with onset received ASC-CM or vehicle for 3 days or 7 days, while spinal cords were removed for Western blot. (A): (a) Representative immuoblots and (b) quantitation of band density showed reduced pp38 expression in SOD1^G93A mice spinal cords after 3 days ASC-CM treatment versus BME treatment. (B): (a) Representative immunoblots and (b) densitometric quantitation demonstrated reduced pp38 expression in 7 days ASC-CM-treated mice compared to BME-treated mice. Unchanged total p38 levels were used as internal loading controls. Values are shown as mean density ± SEM and statistical analyses were performed using one-way ANOVA. *p < 0.05; **p < 0.01; ***p < 0.005; n = 3 per group.