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. 2015 Sep 23;290(47):28097–28106. doi: 10.1074/jbc.M115.680090

FIGURE 3.

FIGURE 3.

Gpx4 ablation resulted in no overt neurodegeneration in the cerebral cortex. A, Western blots showing levels of GPX4, Syn, NeuN, and PSD95 in cortex tissues from Gpx4(f/f) mice and Gpx4NIKO mice on day 6 post TAM treatment (n = 9, male and female). B, quantified levels of GPX4, Syn, NeuN, and PSD95 in cortex tissues. *, p < 0.05. C, detection of rGpx4 by PCR only in nervous tissues from TAM-treated Gpx4(f/f);Camk2α-creERT mice. The image was assembled from different parts of a gel. CC, cerebral cortex; HC, hippocampus; SM, skeletal muscle; Li, liver. D, Western blots showing levels of GPX4, Syn, NeuN, and PSD95 in cortex tissues from Gpx4(f/f) mice and Gpx4(f/f);Camk2α-creERT mice 2 weeks post-TAM treatment. E, quantified levels of GPX4, Syn, NeuN, and PSD95 in cortex tissues from Gpx4(f/f) mice and Gpx4(f/f);Camk2α-creERT mice 2 weeks post-TAM treatment (n = 3, male and female). *, p < 0.05.