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. 2015 Oct 1;290(47):28299–28310. doi: 10.1074/jbc.M115.685511

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Deletion of Ada3 causes defects in chromosome segregation. A, strategy used to assess chromosome mis-segregation in Ada3-deleted cells. B, representative confocal images of DAPI-stained anaphase chromosomes from control or Cre-infected Ada3^FL/FL MEFs. Note that Ada3-deleted cells show various chromosomal segregation abnormalities, such as lagging chromosomes and anaphase bridges (indicated by white arrows). C, quantification of chromosomal segregation defects in control or Cre-infected Ada3^FL/FL MEFs from B. Note that at least 50 anaphase cells each from control (Ctrl) and Cre-infected Ada3^FL/FL MEFs were analyzed for quantification.