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. 2015 Oct 1;290(47):28299–28310. doi: 10.1074/jbc.M115.685511

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Model displaying the role of ADA3 in chromosome segregation. i, ADA3 associates with the centromere by directly binding to CENP-B that interacts with centromeric proteins CENP-A and CENP-C to form functional centromere, which is required for proper chromosome segregation. ii, in conditions where ADA3 protein is depleted, the recruitment of CENP-B at the centromere is diminished, leading to chromosomal segregation abnormalities, viz. anaphase bridges and lagging chromosomes. Note that for the simplicity of the model, the association of ADA3 and centromeric proteins with the centromere is enlarged at only one chromosome and not shown for each chromosome.