FIGURE 6.

HEWL oligomers but not mature fibrillar fragments inhibit hippocampal LTP in vivo. Intracerebroventricular injection (asterisk) of vehicle (distilled water or non-aggregated HEWL) 1 h before high frequency conditioning stimulation (arrow) did not affect LTP (open circles). In contrast, animals injected with HEWL oligomers were unable to maintain LTP (open triangles). Intracerebroventricular injection of sonicated mature fibrils had no effect on LTP (closed circles). Insets show representative EPSP traces at the time indicated. Horizontal bar, 10 ms; vertical bar, 1 mV. Results are the means of three separate experiments.