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The schematic model proposed by the present study. A, under normal conditions, Notch receptors and the expression of their down-stream molecules (such as HES and HEY proteins (30)) are constitutively activated by ADAM10 (and through binding of Notch ligands) and thereby maintain the quiescent state of SCs. B, loss of ADAM10, in turn, suppresses Notch signaling and consequently results in the dysregulated differentiation of SCs. NICD, Notch intracellular domain.
