Table 2.

Proposed criteria for CCUS

Peripheral blood findings	Bone marrow findings	Genetic findings
1 or more of the following:	None of the following:	1 or more of the following:
Hemoglobin, <11 g/dL	≥10% dysplasia in the granulocytic, erythroid, or megakaryocytic lineage	An acquired chromosomal abnormality not diagnostic of a heme malignancy
ANC <1500/μL, 1.5 × 109/L	Myeloblasts comprise ≥5% of total cellularity	Presence of a somatic mutation with a VAF ≥2% in a heme malignancy–associated gene in the peripheral blood or bone marrow
Platelet count <100 000/μL, 100 × 109/L	An acquired chromosomal abnormality specific for MDS/AML
Additional criteria: No other likely cause of cytopenias or evidence of another hematologic disorder.