Table 1.

The number of inflammatory cells, expression of cytokines and transcription factors in normalized relative quantities (NRQ), described as median (IQR) in the tissue of nasal polyps of ECRS and non-ECRS patients, and normal controls

Nasal tissue analysis	Eosinophilic CRS polyps	Non-eosinophilic CRS polyps	Non-CRS controls	Multiple comparison	ECRS vs NC	ECRS vs non-ECRS	Non-ECRS vs NC
	Median (IQR)	Median (IQR)	Median (IQR)	P-value	P-value	P-value	P-value
The number of inflammatory cells
Eosinophils	127.4 (81.4–180.7)	2.5 (0.55–7.3)	0 (0–0.05)	<0.001	<0.001	<0.001	0.0082
T cells (CD3)	29.8 (27.7–72.1)	60.5 (34.6–113.0)	56.2 (37.1–66.3)	0.34	0.52	0.14	0.74
CD4+ cells	3.4 (2.3–7.3)	16.4 (10.0–24.2)	13.3 (10.3–16.5)	0.0016	0.005	0.0014	0.42
CD8+ cells	36.6 (16.2–56.1)	63.2 (42.9–82.1)	34.4 (23.4–58.0)	0.029	0.67	0.022	0.038
mRNA expression of transcription factors
Tbet	0.85 (0.5–1.4)	2.5 (1.2–113.2)	1.7 (1.1–2.7)	0.06	0.17	0.03	0.28
GATA3	0.56 (0.33–0.73)	1.2 (0.54–39.9)	1.0 (0.9–1.9)	0.018	0.003	0.0049	0.92
FOXP3	2.3 (1.9–3.2)	10.0 (6.2–30.8)	2.1 (1.0–4.5)	<0.001	1	<0.001	0.005
RORc	0.37 (0.096–0.49)	0.66 (0.48–10.9)	1.1 (0.91–1.56)	0.007	0.0025	0.0023	0.56
mRNAexpression of key cytokines
IFN-γ	0.77 (0.28–1.2)	5.2 (1.4–16.4)	1.4 (0.81–2.2)	0.003	0.25	0.0015	0.04
IL-5	137.8 (21.3–573.5)	0.11 (0.0–1.1)	0.39 (0.069–1.0)	<0.001	<0.001	<0.001	0.88
IL-13	16.5 (3.9–61.3)	0.3 (0.0–4.5)	0.81 (0.11–3.6)	<0.001	0.006	<0.001	0.67
IL-4	0.62 (0.19–0.98)	0.3 (0.095–0.89)	0.78 (0.17–1.3)	0.58	0.79	0.39	0.38
IL-4R	0.052 (0.036–0.88)	0.11 (0.067–0.27)	0.24 (0.11–0.67)	<0.001	<0.001	0.03	0.04
IL-10	5.3 (2.5–8.1)	8.9 (4.0–268.4)	1.0 (0.93–2.4)	0.005	0.04	0.13	0.002
TGF-β1	2.9 (1.9–4.0)	6.1 (3.6–17.6)	2.4 (1.5–2.9)	0.007	0.28	0.02	0.005
IL-17	4.1 (1.3–12.3)	22.0 (8.3–4534.0)	4.0 (1.6–8.2)	0.042	0.92	0.03	0.03

P < 0.05 were considered to indicate statistical significance (italic values)