Table 2.
Changes in leucocyte count, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) following intensive and weekly GMA in Crohn’s disease patients
| Measurement | Time point | Intensive GMA | Weekly GMA | P value*, intensive vs weekly |
|---|---|---|---|---|
| Leucocyte (/μL) | Baseline | 8005 [6290–9378] | 7100 [5340–7915] | 0.0273 |
| Post GMA | 6950 [5400–8775] | 7160 [5338–8465] | 0.8601 | |
| P value** | ||||
| Baseline vs Post GMA | 0.0461 | 0.6260 | ||
| ESR (mm/hr) | Baseline | 54.5 [37.0–68.0] | 24.5 [9.7–52.5] | 0.014 |
| Post GMA | 30.0 [10.5–51.5] | 26.0 [7.0–47.0] | 0.5480 | |
| P value** | ||||
| Baseline vs Post GMA | 0.0059 | 0.6553 | ||
| CRP (mg/dL) | Baseline | 1.90 [0.60–4.05] | 0.90 [0.40–2.62] | 0.0478 |
| Post GMA | 0.80 [0.12–2.30] | 0.35 [0.195–1.27] | 0.4464 | |
| P value** | ||||
| Baseline vs Post GMA | 0.0941 | 0.0277 |
Data are represented as the median [interquartile range]
*Compared by Wilcoxon-Mann–Whitney test
**Compared by Wilcoxon-Signed-Rank test. GMA, granulocyte and monocyte adsorptive apheresis. For ESR, the number of patients at baseline in the intensive and the weekly GMA arms were 22 and 24, respectively. Normal range: leucocyte 4000–9000/μL, CRP < 0.3 mg/dL, ESR < 10 mm/hr (male); < 15 mm/hr (female)