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. 2015 Nov 19;15:919. doi: 10.1186/s12885-015-1929-y

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© Koehler et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Obatoclax blocks cell growth and induces apoptosis in starving CRC cells. a and b HT29 and SW480 cells were treated with obatoclax in full supplemented medium or starvation as indicated. a Cell growth was assessed by MTT-Assay after 48 h. Cell death was assessed by Flow Cytometry after 48 h. Assays were done in triplicates. Values are expressed as mean ± SD. b Representative Western blots for p62 and LC3 I/II in HT29 and SW480 treated with obatoclax or ABT-737 in full supplemented medium as indicated. c Rel. mRNA levels of LC3 in HT29 cells after 24 h treatment with obatoclax. mRNA levels were quantified by qRT-PCR and normalized to GAPDH as housekeeping gene. Assays are representative of at least three independent experiments . ** = p < 0.01; *** = p < 0.001