Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 19;8:76. doi: 10.1186/s13041-015-0169-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Liu et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 4 — The effect of AMPA inhibitor IEM1460 on behavioral test in the animal model of IBS. a The time course of cannulation surgery, zymosan injection, microinjection, and behavioral tests. b Schematic showing cannula tip placements in the ACC. C-H) The mice injected with zymosan exhibited obvious visceral pain behavior (c), the decreased travel distance (d), vertical counts (e), ambulatory counts (f), stereotypic counts (g), and jump counts (h) in open field test. However, the microinjection with IEM 1460 totally blocked the effects of zymosan in mice. IEM 1460 had no effect in control mice. N = 6 mice per group, ** P < 0.01 vs. control (No cannula), ^# P < 0.05, ^## P < 0.01 vs. zymosan + IEM 1460