Table 1.

Studies performed on chronic pain in the ACC of mice

Chronic pain	ACC	References
Inflammatory pain	Increased synaptic GluA1 subunits	Bie et al., 2011
	Activation of mu opioid receptor inhibits the excitatory glutamatergic transmission	Zheng, 2010
	GluA1 but not GluA2 contributes to LTP	Toyoda et al., 2009
	Increased transmitter release and number of available vesicles	Toyoda et al., 2009
	Enhanced presynaptic glutamate release and neuronal cAMP	Wu et al., 2008
	Enhanced presynaptic neurotransmitter release	Zhao et al., 2006
Inflammatory pain & Neuropathic pain	Long-term temporal imprecision of information coding	Li et al., 2014
	Activation of Erk	Wei et al., 2008
Neuropathic pain	Postsynaptic GluA1 accumulation	Chen et al., 2014
	Long-term enhancement of cortical-spinal projecting cells	Chen et al., 2014
	Disinhibition of the ACC	Blom et al., 2014
	Long-term changes in spontaneous membrane-potential oscillations	Ning et al., 2013
	LTD impairment	Kang et al., 2012
	Activation of PKMζ	Li et al., 2010
	Reduced cannabinoid receptor 1 activity	Hoot et al., 2010
	Increased transmitter release	Toyoda et al., 2009
	Presynaptic and postsynaptic amplifications	Xu et al., 2008
Bone cancer pain	LTD impairment	Chiou et al., 2012
Visceral pain	Facilitation of synaptic transmission	Wang et al., 2013
	Increased expression of Fos in the CNS	Zhang et al., 2014
	Long-term enhancement of AMPA receptors in the ACC	This study