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. 2015 Sep 23;24(24):6944–6957. doi: 10.1093/hmg/ddv398

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Figure 9. — Adgrv1^−/−, Ush2a^−/− and Dfnb31^neo/neo mice have different degrees of hearing loss. Hearing function of 1-month-old Adgrv1^−/−, Ush2a^−/− and Dfnb31^neo/neo mice was assessed by ABR tests at frequencies of 4, 5.6, 8.0, 11.3, 16.0, 22.6, 32.0 and 45.2 kHz. Compared with wild-type controls, these mutant mice have significantly elevated ABR thresholds across all the frequencies tested (P < 0.01, 2-way ANOVA with post hoc tests). Threshold differences between Adgrv1^−/− and Ush2a^−/−, Adgrv1^−/− and Dfnb31^neo/neo, and Ush2a^−/− and Dfnb31^neo/neo mice are statistically significant (P < 0.01) at 5.6, 8.0, 11.3 and 16.0 kHz. Adgrv1^−/− and Dfnb31^neo/neo mice have the most and least severe hearing loss, respectively. For comparison, ABR results on Pdzd7^−/− mice at P21–P28 are also shown here (24). Threshold differences between Ush2a^−/− and Pdzd7^−/− mice are not statistically significant at any tested frequency. Numbers in parentheses indicate numbers of animals tested. Error bars, standard error of the mean.