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. 2015 Sep 24;24(24):6958–6974. doi: 10.1093/hmg/ddv399

Figure 7.

Figure 7.

Expression levels of selected genes expressed in the RPE of Adamtsl4tvrm267 mutants. (A) Comparison by qRT–PCR of mutant and WT gene expression of Lrat, Rgr and Rpe65 in posterior eyecups at 1, 3 and 6 months indicates progressive loss of RPE-specific expression (n = 3). (B) RPE-enriched gene expression at 6 months indicates significant reduction of Cdh2, trending loss of Fbn1, RPE-specific loss of expression of Lrat, Rgr and Rpe65 and a significant upregulation of Col18a1 (n = 4). Error bars reflect propagating error as defined in the Materials and Methods section. +P = 0.052, *P < 0.05, **P < 0.01.