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Mouse HPRT minigenes used in this study. Numbered black boxes represent exons. The mouse minigene is driven by the PGK promoter (grey box) and all but the last two introns are removed. Partial nucleotide, and amino-acid, sequences from exon 6 are shown for the wild-type (WT) allele and for alleles modified to carry an I-SceI site (boxed) with (mHP-I*-RT) or without (mHP-I-RT) an adjacent stop codon. Altered residues are shown in bold.
