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. 2015 Nov 18;1(1):e000155. doi: 10.1136/rmdopen-2015-000155

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Time to discontinuation of TNF-inhibitors (TNF-i) and non-TNF-inhibitors (non-TNFi), non-adjusted (non-adj) and adjusted (adj) for propensity score survival curves. (A) First biologic. (B) Second biologic. (C) First biologic with onset ≥2005. (D) Second biologic with onset ≥2005. TNF inhibitor versus non-TNF inhibitor (first biologic): Whole follow-up, unadjusted HR 0.48 (0.34 to 0.69), adjusted HR 0.49 (0.34 to 0.71); Started biologic ≥2005: unadjusted HR 0.59 (0.40 to 0.87), adjusted HR 0.60 (0.41 to 0.90). TNF inhibitor versus non-TNF inhibitor (second biologic): Whole follow-up, unadjusted HR 0.64 (0.48 to 0.84), adjusted HR 0.68 (0.51 to 0.90); Started biologic ≥2005: unadjusted HR 0.78 (0.58 to 1.06), adjusted HR 0.82 (0.60 to 1.12).