Table 2.
Donor |
Recipient |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Serostatus (IgG) |
No. of clonotypes CD4+ cells preMOB | No. of clonotypes CD4+ cells postMOB | No. of clonotypes CD8+ cells preMOB | No. of clonotypes CD8+ cells postMOB | Virus reactivation |
||||||
No. | Gender | Age | Donor type | CMV | EBV | CMV | EBV | ||||
1 | M | 57 | SIB | neg. | pos. | 2454 | 2288 | 887 | 840 | No | Yes |
2 | M | 30 | MUD | neg. | pos. | 3034 | 3110 | 2350 | 2369 | No | No |
3 | M | 20 | MUD | neg. | pos. | 2198 | 2604 | 1938 | 2231 | Yes | No |
4 | M | 33 | SIB | neg. | neg. | 2786 | 2825 | 1984 | 1254 | No | No |
5 | F | 51 | SIB | neg. | pos. | 2562 | 2596 | 1871 | 2140 | No | No |
6 | M | 23 | MUD | pos. | pos. | 2380 | 1542 | 1489 | 1400 | Yes | Yes |
7 | M | 58 | SIB | neg. | pos. | 2410 | 3061 | NA | NA | No | No |
8 | M | 50 | MUD | pos. | pos. | 2617 | 2674 | 1503 | 1295 | No | No |
9 | M | 44 | MUD | pos. | pos. | NA | NA | 995 | 1085 | Yes | No |
10 | F | 61 | SIB | neg. | pos. | 2020 | 2629 | 1433 | 1577 | No | No |
11 | F | 51 | SIB | neg. | pos. | 2773 | 2810 | 2592 | 1519 | No | No |
12 | M | 45 | MUD | pos. | pos. | 2655 | 2552 | 1903 | 2027 | Yes | Yes |
13 | M | 30 | MUD | neg. | pos. | 2575 | 2687 | 2296 | 2427 | Yes | Yes |
14 | M | 51 | MUD | neg. | pos. | 2403 | 2143 | 941 | 1520 | Yes | No |
15 | M | 48 | SIB | neg. | pos. | 2493 | 2065 | 508 | 1088 | Yes | No |
16 | M | 20 | MUD | pos. | neg. | 2373 | 2084 | 2054 | 1729 | Yes | No |
17 | M | 32 | MUD | pos. | pos. | 2859 | 2503 | 1642 | 1666 | Yes | No |
18 | M | 48 | MUD | pos. | pos. | 2189 | 2292 | 941 | 1380 | Yes | Yes |
19 | M | 40 | MUD | neg. | neg. | 2674 | 2602 | 2141 | 1668 | No | No |
20 | M | 41 | MUD | neg. | neg. | 2054 | 2795 | 1764 | 2381 | No | No |
21 | M | 49 | MUD | neg. | pos. | 2853 | 2577 | 1813 | 1508 | No | No |
22 | M | 40 | SIB | pos. | pos. | 2245 | 1866 | 2400 | 2021 | No | Yes |
23 | M | 45 | MUD | pos. | pos. | 2294 | 2477 | 1434 | 1414 | Yes | Yes |
Gender, age, donor type, virus (CMV and EBV) status, and number of clonotypes of the CD4+ and CD8+ T cell compartments of stem cell donors before and after G-CSF mobilization as well as clinical data (CMV and EBV reactivation) of corresponding recipients.
CMV, cytomegalovirus; EBV, Epstein–Barr virus; F, femal; G-CSF, granulocyte colony-stimulating factor; MUD, matched unrelated donor; M, male; NA, not available; SIB, sibling donor.