Table 2. Levels of expression of membrane-bound IL-1 type 1 and 2 receptors on intact CD3⁺, CD19⁺, and CD14⁺ PBMC subpopulations and on CD14⁺ cells from both unstimulated and LPS-stimulated PBMC cultures from 150 healthy individuals.

	Median (quartiles)
	Percent of cells expressing receptors		Number of receptors per cell
	IL1R1	IL1R2	IL1R1	IL1R2
Intact CD3+ cells	10.1 (7.1–13.9)1	2.9 (1.5–5.7)	1148.9 (931.8–1537.5)1	611.3 (485.4–750.6)3
Intact CD19+ cells	3.4 (2.6–5.2)2	2.8 (2.0–4.8)	1597.0 (1222.6–1908.9)2	1128.1 (960.4–1369.4)
Intact CD14+ cells	61.0 (40.0–74.6)4	2.9 (1.5–7.4)4	920.6 (731.5–1226.9)4	1035.4 (801.3–1389.5)4
Unstimulated CD14+ cells	46.1 (28.6–70.3)5	14.5 (8.9–59.4)5	1568.7 (1306.0–1981.8)5	1621.3 (1341.3–2155.2)5
LPS-stimulated CD14+ cells	75.7 (64.2–82.0)	8.4 (4.3–28.7)	3519.9 (2865.0–4473.6)	1507.0 (1155.3–1915.4)

Abbreviations: IL1R, IL-1 receptor; LPS, lipopolysaccharide; PBMC, peripheral blood mononuclear cell.

Data expressed as medians (interquartile range).

Mononuclear cells (2×10⁶/ml) were cultivated in the absence and presence of LPS (E. coli serotype 055:B5) at a concentration of 200 ng/ml for 24 h.

¹Significant difference from intact CD14⁺ cells (P<0.001).

²Significant difference from intact CD3⁺ and CD14⁺ cells (P<0.001).

³Significant difference from intact CD19⁺ and CD14⁺ cells (P<0.001).

⁴Significant difference from CD14⁺ cells from unstimulated PBMC cultures (P<0.001).

⁵Significant difference from CD14⁺ cells from LPS-stimulated PBMC cultures (P<0.05).